Fasudil, a Rho-kinase inhibitor, prevents intima-media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow-induced vascular remodeling
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چکیده
منابع مشابه
Fasudil, a Rho-kinase inhibitor, prevents intima-media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow-induced vascular remodeling
Vascular remodeling in response to hemodynamic alterations is a physiological process that requires coordinated signaling between endothelial, inflammatory and vascular smooth muscle cells (VSMCs). Extensive experimental and clinical studies have indicated the critical role of the Ras homolog gene family, member A/Rho‑associated kinase (ROCK) signaling pathway in the pathogenesis of cardiovascu...
متن کاملFlow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening.
OBJECTIVE Vascular remodeling of the carotid artery with intima-media thickness (IMT) is an important predictive factor for human cardiovascular disease. We characterized a mouse model of vascular remodeling. METHODS AND RESULTS The left external and internal carotid branches were ligated so that left carotid blood flow was reduced to flow via the occipital artery. In response to partial liga...
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motility, migration, proliferation, differentiation, and apoptosis. Activation of Rho/ROCK is considered to play a major role in the pathogenesis of several cardiovascular diseases, including PH,5 and thus is a new therapeutic target for PH (Figure). Fasudil is one of the most frequently used ROCK inhibitors, and was approved as a therapeutic agent for vasospasm after arachnoid hemorrhage. Seve...
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P ulmonary hypertension (PH) is characterised by progressive elevation of pulmonary artery pressure and pulmonary vascular resistance. Pathohistological findings have demonstrated that PH is associated with abnormal vascular structures, including medial and/or intimal hypertrophy, concentric or eccentric intimal fibrosis, obstruction in the arterial lumen, and aneurysmal dilatation. Patients wi...
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The mechanisms underlying the pathogenesis of idiopathic pulmonary fibrosis (IPF) involve multiple pathways, such as inflammation, epithelial mesenchymal transition, coagulation, oxidative stress, and developmental processes. The small GTPase, RhoA, and its target protein, Rho-kinase (ROCK), may interact with other signaling pathways known to contribute to pulmonary fibrosis. This study aimed t...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2015
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2015.4409